Abstract Background Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle.Origin choice is linked to cell growth, differentiation, and replication stress.Although various genetic and epigenetic signatures have been linked to the replication efficiency of origins, there i
Abstract Background Ischemic colitis can occur after colectomy and is sometimes difficult to treat.We report 4 cases of refractory, delayed onset, regional congestive colitis occurring on the anal side of the anastomosis after laparoscopic left hemicolectomy.Case presentation A total of 191 patients underwent surgery for left colon cancer (transver
A century worth of research has linked multiple cognitive, perceptual and behavioral states to various brain oscillations.However, the mechanistic roles and circuit underpinnings of these oscillations remain an area of active study.In this review, we argue that the advent of optogenetic and related systems neuroscience techniques has shifted the fi
European heathland habitats are cultural landscapes derived from previously-forested ecosystems.Heathlands are of significant conservation interest but have experienced prolonged degradation due to a range of factors including overgrazing by domestic livestock.There is growing recognition of the need to restore upland landscapes to produce a divers